With the big money at play, including the stock market, how willing will "science" be to admit that the money sunk into the eradication efforts so far will yield less benefit than had been forecast into the markets?

Yeah, there's something of the 'fools' paradise' in this.

Assuming the vaccine becomes markedly less effective over the course of continued mutations, will governments and corporations continue to promote their use?

That's like saying will corporations stop looking for ways to increase sales? As mutations arise we'll likely see 'All New Improved' vaccines. I'd be aiming for a perpetual yearly flu-shot scenario if i was big-Pharma boss.

This is something we touched on before - authorities say it 'won't be compulsory' but it will through compliance measures. We talked about 'no jab no fly', now there's this:

"Employers want the power to require workers to get the COVID-19 vaccine and stand them down from work without pay if they refuse, warning that bosses and employees will be left vulnerable if co-workers decline to be vaccinated."

https://www.theaustralian.com.au/nation/politics/call-from-business-to-bar-workers-who-... (paywall)